Intriguingly, upon removal of GDF-15 from this model, T2DM status became independently associated with liver VCTE-derived kPa measurement [β coefficient = 0.09 (0.18–0.17), p = 0.015], whereas age, sex, total body fat, e-GFR and AST were not associated with liver VCTE-derived kPa measurement (model fit R2 = 0.152; p = 0.03). This evidence concerns the gene GDF15 and type 2 diabetes mellitus.