GDF15 and type 2 diabetes mellitus: Furthermore, in a fully adjusted model where T2DM, GDF-15 concentrations, age, sex, total body fat percentage, e-GFR and AST concentrations were entered as key covariates (identified from multivariable linear regression modelling see Supplementary Table 3) and ≥F2 fibrosis status was the outcome variable, only serum GDF-15 concentrations were associated with ≥F2 fibrosis (Table 3 – model 3).