In a model where ≥F2 fibrosis status was the outcome and HOMA-IR, T2DM status and GDF-15 concentrations were the explanatory variables, only GDF-15 concentration (and not HOMA-IR or T2DM) was associated with ≥F2 fibrosis [OR = 1.002 (1.001–1.003), p = 0.004, for each 1 pg/ml of GDF-15]. The gene discussed is GDF15; the disease is type 2 diabetes mellitus.