These data suggested that GDF-15 was potentially involved in the associations between T2DM and ≥F2 fibrosis as well as between T2DM and ≥F3 fibrosis (Sobel test statistics 2.90, p = 0.004; and 2.71, p = 0.007, for ≥F2 fibrosis and ≥F3 fibrosis, respectively). Here, GDF15 is linked to type 2 diabetes mellitus.