Whilst evidence does suggest that GDF-15 may have a pro-fibrogenic role within the liver and we found that HbA1c explains almost 30% of the variance in GDF-15 concentrations, our findings showing that GDF-15 may be involved in the known association between T2DM and liver fibrosis should be interpreted with caution. The gene discussed is GDF15; the disease is type 2 diabetes mellitus.