Our findings that a serum GDF-15 concentration of 1193.7 pg/ml was the optimal threshold for predicting ≥F3 fibrosis are consistent with other recent work carried out in an Asian NAFLD cohort where a serum GDF-15 concentration of 1520 pg/ml was found to be the optimal threshold for predicting histologically proven advanced fibrosis (≥F3 liver fibrosis) [13]. This evidence concerns the gene GDF15 and fibrosis.