Consistent with the findings in mice, the higher Notch1 expression was observed in the SNHG22high subtype GC clinical samples (Fig. 7F), and lower expression of E-cadherin, EAF2, ADRB2, rap1GAP and RUNX3 expression were ovserved in the SNHG22high subtype GC clinical samples (Fig. 7G–K). The gene discussed is RAP1GAP; the disease is gastric cancer.