By taking advantage of transcriptomics technology, a previous study found that TFAM loss led to increased angiogenesis and invasion as well as genes relates to amino acid metabolism [e.g., SLC1A5 (ASCT2) and SLC1A4 (ASCT1)] in melanoma cells [49], suggesting that, in order to gain better anti-cancer therapeutic efficacy, it is important to define molecular and metabolic features upon mitochondrial manipulations in order to target the correct cue(s) for combinational therapy. Here, SLC1A4 is linked to melanoma.