It is well known that weight reduction and regular physical exercise improve insulin sensitivity and decreases triglyceride levels.8 Aerobic physical activity such as 25–30 km brisk walking per week may increase HDL cholesterol by 0.08–0.15 mmol/L.8 Overweight and especially abdominal adiposity contributes to overall dyslipidaemia and these conditions were common in this study population that also showed both excessive weight loss and weight gain after 3 months. This evidence concerns the gene INS and inherited lipid metabolism disorder.