TIA and stroke share the same risk factors.1 2 A systematic review revealed that people after stroke are highly sedentary, in particular during the acute phase,3 which may affect body composition negatively.1 4 5 Loss of muscle mass and increase of fat mass may contribute to insulin resistance and impaired glucose control.4 Beyond increasing muscle mass and reduction of fat mass,5 6 physical activity and exercise may improve lipid and glucose metabolism. The gene discussed is INS; the disease is stroke disorder.