HLA-G CAR shows antitumor activity both in vitro and in vivo in an HLA-G-expressing hematopoietic tumor model based on K562 and JEG-3 cells.16 However, it is not clear whether the antitumor efficacy of HLA-G-redirected CAR is effective in solid tumor models. This evidence concerns the gene HLA-G and hematopoietic and lymphoid cell neoplasm.