A recent study revealed that the HLA-G-expressing macrophages are of M2 phenotype and cause limited degranulation and cytotoxic capacity in NK cells through engagement of LILRB1.22 In addition, HLA-G-expressing immune cells such as dendritic cells and T cells have been reported to promote tumor development by inhibiting antitumor immunity.52 Furthermore, we found that some HLA-G-positive immune cells were present in TNBC, GBM, PA, and OV tumor sections. Here, HLA-G is linked to neoplasm.