APP and Cognitive impairment: Interestingly, in mild cognitive impairment (MCI) patient brain samples, we observed nuclear localization of 6E10 positive and ZNF598 positive signals (Additional file 1: Fig. S5g), consistent with previous observation of stage-specific nuclear/perinuclear mOC78 positive amyloid signals [55] and suggesting disease stage-dependent modulation of APP.C99 and RQC factors.