PSEN1 and Alzheimer disease: To obtain in vivo evidence for the relevance of translation stalling to AD pathogenesis in a mammalian system, we used the 5xFAD mouse model expressing human APP and PSEN1 with five FAD mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP and the M146L and L286V mutations in PSEN1.