The analysis confirmed that not only in vitro myeloid cells, but also in vivo primary murine cells transcriptional expression of Wnt5a in arthritis associated with enrichment of active marks such as H3K36me3, and H3K27Ac, and reduced levels of H3K27me3 around the TSS region of respective genes (Fig. 6e). This evidence concerns the gene WNT5A and arthritic joint disease.