This analysis identified a number of genes that are differentially essential in male or female KRAS-mutant NSCLC, PDAC, and CRC models (Fig. 3a-f and Additional file 7: Table S6, Additional file 8: Table S7, Additional file 9: Table S8, Additional file 10: Table S9, Additional file 11: Table S10, Additional file 12: Table S11). The gene discussed is KRAS; the disease is colorectal carcinoma.