We then plotted the set of differentially essential genes against the differentially expressed genes in KRAS-mutant NSCLC, PDAC, and CRC models (Fig. 3a, c, e and Additional file 7: Table S6, Additional file 8: Table S7, Additional file 9: Table S8, Additional file 10: Table S9, Additional file 11: Table S10, Additional file 12: Table S11) and found little overlap between these gene lists. This evidence concerns the gene KRAS and non-small cell lung carcinoma.