In addition, studies have shown that the Ras protein activator-like 1 protein (Rasal1) negatively regulates the P21Ras-ERK pathway in T cells, thereby inhibiting the activation of T cells to reduce the antitumor immunity of T cells, while RASAL1 knockdown was shown to enhance the antitumor activity of T cells in B16 melanoma and EL-4 lymphoma [134]. The gene discussed is RASAL1; the disease is melanoma.