The efficacy of a second-generation derivative, omaveloxolone (RTA408), has recently been assessed in a preclinical model for diabetic chronic non-healing wounds [277] and, interestingly, omaveloxolone is now being tested in phase-II clinical trial for the Friedreich’s ataxia (FRDA), a neurodegenerative condition in which NRF2 activation is suppressed [278, 279]. The gene discussed is NFE2L2; the disease is Friedreich ataxia.