Experimental evidence revealed a significant increase in KEAP1-RBM45 binding in cytosolic fractions from ALS lumbar postmortem spinal cord compared to controls; in addition, it has been demonstrated that RBM45 can bind p62 and that RBM45-p62 cytoplasmic colocalization was increased in ALS spinal cords [247]. Here, KEAP1 is linked to amyotrophic lateral sclerosis.