KEAP1 and amyotrophic lateral sclerosis: In an effort to clarify the role of the KEAP1-NRF2 pathway in ALS, it has been revealed that the transfection of the mouse MN-like hybrid cell line (NSC-34) with the human SOD1G93A gene causes damage in the Nrf2/ARE signalling and a reduced ability of cells to react to OS.