Though the molecular mechanism(s) underpinning MCP-1’s regulation during latency is yet to be elucidated, it is certainly plausible the viral-encoded GPCRs expressed during latency [57, 63, 145, 150, 151], such as US28, may leverage MCP-1’s upregulation to its own advantage, perhaps promoting dissemination in the initial stages of viral infection. Here, CCL2 is linked to viral infectious disease.