In contrast, Hellevik et al. [98] reported down-regulated MMP-1 from irradiated lung-CAFs, and also Arshad et al. [121] observed reduced secretion of TGF-β and MMP after simultaneous irradiation of fibroblasts and cancer cells in co-cultures (1 × 10 Gy) [121]. This evidence concerns the gene TGFB1 and cancer.