In the TME, the presence of CAFs and their secretion of chemokines and cytokines such as CCL2, CCL5, CCL17, IL-1, IL-6, IL-13, and IL-26 can favor a tumor-promoting Th2 and Th17 immune response, at the expense of tumor-protective Th1 responses [75, 76]. Here, IL1B is linked to neoplasm.