AKT1 and autoimmune thrombocytopenic purpura: Another study found that eltrombopag can induced relevant changes in the hematopoiesis, platelet activation as well as megakaryocyte differentiation with the overexpression of the genes ITGB3 [28].Our results showed that the expression of ITGB3 in the ITP patient group was lower than that in the control group, suggesting that the overexpression of autophagy may be caused by the downregulation of AKT activation by ITGB3.