Among the identified DEGs, we focused on 8 up-regulated genes (SNTB1, PLEKHG4, JPH1, CTPS1, LRRC6, LY6G6F, PLCB4 and LRP8; Fig. 1a) that had not been extensively studied in CRC. The gene discussed is LY6G6F; the disease is colorectal carcinoma.