Interestingly, high expression of MT1G was related to the poor prognosis of HCC (Fig. 3B), and Astragalus membranaceus could significantly down-regulate MT1G in HCC cells (Fig. 1C), suggesting that Astragalus membranaceus may improve prognosis of HCC by down-regulating MT1G. The gene discussed is MT1G; the disease is hepatocellular carcinoma.