Post hoc analysis showed as follows: (1) serum ANP was higher in the DN group than in the control (T2DM) group [18–20]; (2) serum ANP was higher in the macroalbuminuria stage of DN; (3) serum ADP, TNF-α, and IL-6 levels were increased in the presence of DN; (4) serum ANP level was significantly positively correlated with ADP, TNF-α, and IL-6 levels; (5) serum ANP was positively correlated with DN stage after adjusting for the risk factors; and (6) ANP was level demonstrated to be an independent risk factor for DN. This evidence concerns the gene IL6 and type 2 diabetes mellitus.