Phosphodiesterase type 5 (PDE-5) inhibitors, endothelial receptor antagonists (ERAs), prostacyclin analogs and soluble guanylate cyclase (sGC) activators were therapeutic agents used by the CTEPH patients, which included sildenafil, tadalafil, vadenafil, ambrisentan, bosentan, beraprost and iloprost. This evidence concerns the gene SGCB and chronic thromboembolic pulmonary hypertension.