After adjusting for the potential confounders, including age (every 10 years), sex, BMI (normal, overweight, obesity), hypercholesterolemia, hypertriglyceridemia, hs-CRP (< 1 mg/L, 1–3 mg/L, > 3 mg/L), hyperbilirubinemia, elevated alanine aminotransferase, diabetes, family income, educational background, marital status, salt consumption, current smoker, drinking status, physical activity and family history of cancer, a statistically significant association of HBV infection with the risk of CRC was observed in the adjusted SD models (HRSD = 1.77, 95% CI:1.11–2.84). The gene discussed is GPT; the disease is familial hypercholesterolemia.