Mortality in both Ca/Sa IAI (i.p.)and Ca BSI (i.v.)is attributable to sepsis as evidenced by hypothermia observed in these animals as well as significantly high M-CASS scores and increased systemic proinflammatory cytokine production (IL-6 and TNF-α) compared to those in vaccinated mice before they succumb. This evidence concerns the gene IL6 and Sepsis.