The second novel association was between lower risk of childhood asthma and a burden of rare pLOF and deleterious missense variants in SLC27A3 (3,787 carriers; OR = 0.65, 95% CI 0.55 to 0.76, P = 8.2 × 10−8), which was supported by the following additional observations. The gene discussed is SLC27A3; the disease is asthma.