MIF and systemic sclerosis: MIF is a key mediator of various inflammatory diseases that varies form autoimmune diseases such as Rheumatoid Arthritis (RA), Systemic Sclerosis (SS), Systemic Lupus Erythematosus (SLE) and Multiple Sclerosis (MS), to infectious diseases such as Malaria, Tuberculosis, Leishmania and others [24,38,39,40,41,50,54,55,63,64,65].