1. The essential and beneficial contribution of MIF in physiological levels, to the crucial anti-infection immune responses to the Ov parasitic worm, and to other infectious organisms reported in subjects in NS-affected zones, 2. The detrimental contribution of elevated MIF to the neurotoxic autoimmunity in NS, directed against Glutamate receptors [21] and Leiomodin-I [20] 3. The gene discussed is MIF; the disease is Autoimmunity.