As final step, to exclude that the association was biased by additional factors such as ADAMTS13 consumption during DVT event or drug administration, we repeated the analyses considering the 167 DVT cases whose plasma sample were collected ≥ 3 months from the acute event and/or not during anticoagulant therapy confirming our results (S3 Table). This evidence concerns the gene ADAMTS13 and deep vein thrombosis.