AEs leading to abemaciclib dose adjustments in the Japanese subpopulation were most commonly increased ALT (dose reduction: 15.8%; dose omission: 21.1%), neutropenia (dose reduction: 13.2%; dose omission: 18.4%), and diarrhea (dose reduction: 13.2%; dose omission: 13.2%). The gene discussed is GPT; the disease is neutropenia.