For examples, UTX loss is a driver of bladder cancer (Nickerson et al. 2014); UTX cooperates with MLL4 to promote cell proliferation and invasiveness in breast cancer (Kim et al. 2014); while another study reports that UTX inhibits breast cancer stem cell properties, suggesting its tumor surpressing role (Choi et al. 2015). This evidence concerns the gene KMT2B and urinary bladder carcinoma.