Accumulating studies indicated UTX plays a key role in the occurrence and development of many cancers (Barrows et al. 2020; Gozdecka et al. 2018; Schulz et al. 2019), but the functional mechanism of UTX in NSCLC remains unclear, and the understanding of the network of upstream regulatory mechanisms of UTX is still unknown. This evidence concerns the gene KDM6A and non-small cell lung carcinoma.