KDM6A and urinary bladder carcinoma: For examples, UTX loss is a driver of bladder cancer (Nickerson et al. 2014); UTX cooperates with MLL4 to promote cell proliferation and invasiveness in breast cancer (Kim et al. 2014); while another study reports that UTX inhibits breast cancer stem cell properties, suggesting its tumor surpressing role (Choi et al. 2015).