NFE2L2 and squamous cell carcinoma: One tumor harbored a known deleterious missense mutation in the TP53 tumor suppressor gene, and another tumor harbored a small in-frame deletion in the NFE2L2 gene (also known are NRF2), which affected a known mutational hotspot in the gene recurrently targeted by missense variants or similar small in-frame indels in squamous cell carcinomas of the lung, esophagus, and oropharynx.