CD63 and cancer: Upon these studies, researchers demonstrated the relationship between MN and nEXO (exosomes that contain gDNA and other nuclear contents), MN and gDNA both present in cancer-derived exosomes, on account of the instability of the MN envelope, nuclear membrane can effortlessly collapsed to release its nuclear contents, once it does, the MVB which situated near early endosome and MN will interact with the collapsing MN, and tetraspanin CD63 soon surround the disrupted MN to form a gDNA-nuclear proteins complex.