IGKV2D-26 and cancer: In K562 cells, intracellular uptake ofcompound C was mediated by α5β1 integrin, as demonstrated by a strong reduction of internalizationinduced by pretreatment with an antibody anti-α5.Superimposable results were obtained for compound B (Figure 3, panel b): it wasinternalized in a concentration-dependent manner in both Jurkat andK562 cancer cells, and its intracellular uptake was mediated by α4 integrin in Jurkat cells and by α5 integrinin K562 cells.