Meta-analysis conducted on 99 studies involving 62 739 cases in the Caucasian and Asian populations has shown that various polymorphisms of SERPINE1 may be used as biomarkers for atherosclerotic diseases, including atherosclerosis, coronary artery disease, myocardial infarction (MI) and cerebral infarction. The gene discussed is SERPINE1; the disease is coronary artery disorder.