TLR8ko mice show salivary adenitis, cytokines, and anti-SSA and anti-SSB autoantibodies, which were not present in TLR7/8KO mice, suggesting that these changes depend on TLR7, further confirming the important role of TLR7 signaling in the local and systemic manifestations of SS [35] (Table 1). Here, SSB is linked to synovial sarcoma.