FOXP3 and multiple sclerosis: In addition to the evidence of its role in tumor biology, some studies have suggested that miR-27a expression was upregulated in the T cells of patients with multiple sclerosis and that in murine T cells, it impaired regulatory T cell (Treg) generation by downregulating runt-related transcription factor 1 (RUNX1) and then the forkhead box P3 (Foxp3), i.e., the master transcription factor in maintaining differentiation and suppressive function of Tregs [69].