However, another case-control study with 362 obesity patients and 127 controls found that none of the representative SNPs in the Dio2 gene were associated with obesity or BMI, including Thr92Ala [26], which was further verified in three other studies among diabetes patients [12, 27, 28] and one among thyroidectomized patients [8]. Here, DIO2 is linked to obesity due to melanocortin 4 receptor deficiency.