EPCAM and lung carcinoma: It was reported that H3K9 histone methyltransferase G9a enhanced the level of H3K9 dimethylation, which contributed to the recruitment of the transcription cofactors HP1, DNMT1, and HDAC1 into the promoter region of the cell adhesion molecule Ep-CAM, thus inhibiting the expression of Ep-CAM and promoting the invasion and metastasis of lung cancer [40].