Besides the impacts on monocytes and macrophages, sinomenine also inhibits proliferation of lymphocytes from mouse spleen, antibody production by B cells, and transmigration of granulocytes across the IL-1β activated human umbilical vein endothelial cells monolayer, conducing to alleviate the progression of atherosclerosis (31, 38, 45). Here, IL1B is linked to atherosclerosis.