PCSK9 and metabolic syndrome: Supplementary Material in the present study showed that SBC-115076 put no effect on the expression of LXRα in THP-1 macrophages with or without Hcy. When incubated with T0901317 to activate LXRα, PCSK9 protein expression was decreased. The present results suggested that ABCA1 and ABCG1 might be the downstream target genes regulated by PCSK9 in Hcy-related dyslipidemia of macrophages, and ABCG1 is a new target in the Hcy-activated PCSK9 pathway. And Hcy might affect macrophage cholesterol metabolism by inhibiting the ABCA1 and ABCG1-mediated cholesterol efflux by activating LXR/RXR (18).