AMPK activation reverses increased protein O-GlcNAcylation, which is associated with cardiac hypertrophy, mainly through controlling the glutamine: fructose-6-phosphate aminotransferase (GFAT) phosphorylation, resulting in a decrease in O-GlcNAcylation of proteins such as troponin T (70). Here, PRKAA2 is linked to cardiac hypertrophy.