PFKFB3 and Sepsis: Data from genome-wide gene expression profiles show that Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3) is the most upregulated gene among the glycolytic genes in LPS-stimulated macrophages (10), indicating a potential role of PFKFB3 in LPS-induced sepsis.