PFKFB3 and Sepsis: To determine the contribution of Pfkfb3-mediated glycolysis in macrophages to LPS-induced sepsis, we generated myeloid-specific Pfkfb3 deficient mice (Pfkfb3ΔMφ) and control mice (Pfkfb3WT) by intercrossing Pfkfb3flox/flox mice with Lysm-Cre mice (Figures 2A,B).