HMGB1 and Hyperglycemia: In the retina, the exosomes derived from human U-MSCs (huc-MSCs) expressing miR-126 demonstrated remarkable therapeutic effects by decreasing hyperglycemia associated with retinal inflammation by downregulating the high-mobility group box 1 expression (HMGB1) in diabetic rats and human retinal endothelial cells (HREC) (147).