Meanwhile, mammalian STE20-like kinase 1 (MST1) is upregulated after myocardial infarction and increases mitochondrial fission through the JNK-DRP1 (DJ-1) cell signal transduction pathway, leading to cardiomyocyte fibrosis and aggravating myocardial damage (40). The gene discussed is DNM1L; the disease is myocardial infarction.