DNM1L and ischemia reperfusion injury: Indeed, treatment of the heart with Mdivi-1 and P110 elicited a protective effect against ischemia-reperfusion injury (35, 42, 50), as DRP1 inhibitors not only maintain mitochondrial morphology but also reduce calcium ions in the cytoplasm, inhibit the opening of MPTP, and inhibit cardiomyocyte apoptosis, thereby reducing myocardial damage.