Three BC patients had an episode of pulmonary embolism; 2 (treated with anti-vascular endothelial growth factor agents) developed uncontrolled arterial hypertension; 2 were found to have AF; 1 had cardiac tamponade; 1 an episode of takotsubo syndrome and 1 a fatal ischaemic stroke (late after anticancer treatment completion). The gene discussed is VEGFA; the disease is Tako-tsubo cardiomyopathy.