Under hypoxic conditions, HIF-1α promotes the occurrence of glycolysis in tumor cells by activating the expression of key protein involved in extracellular glucose input such as glucose transporter 1 (GLUT1) and intracellular glycolytic enzymes such as phosphofructokinase 1 (PFK1) (Quiroga et al., 2021; Zhang et al., 2021). This evidence concerns the gene PFKM and neoplasm.