TGF-β, IL-6, HIF1α, β-catenin, vimentin, casein kinase, and several EMT-inducer microRNAs (miRNAs) such as miR-301a-3p, miR-146a, miR-155, and miR-32-5p in tumor-derived exosomes are essential factors in the EMT mechanism (Mashouri et al., 2019). The gene discussed is IL6; the disease is neoplasm.