HSP70 could block the seven in absentia homolog 1 (Siah1)– mediated ubiquitination of AIMP2-DX2 by interacting with AIMP2-DX2, thereby maintaining the stability of AIMP2-DX2 and further enhancing AIMP2-DX2–induced cell transformation and cancer progression (Lim et al., 2020). This evidence concerns the gene AIMP2 and cancer.