Coll-SanMartin et al. observed that tRNA isopentenyltransferase 1 (TRIT1) catalyzed the N6-isopentenyladenosine (i6A) modification at the 37th position of tRNAs, and it showed gene amplification–related overexpression in small cell lung cancer (Coll-SanMartin and Davalos, 2021). This evidence concerns the gene TRIT1 and small cell lung carcinoma.