AFP and hepatocellular carcinoma: Plasma three circRNAs (circ_0009582, circ_0037120, and circ_0140117) were overexpressed in HCC patient, and the combination of the three circRNAs and AFP acquired both valuable positive predictive value (PPV) and negative predictive value (NPV) of 95%, suggesting that these three circRNAs can predict HBV-associated HCC patients or healthy individuals (116).