TP53 and hepatocellular carcinoma: Relevant research results show that HBsAg promotes HCC development by inducing non-mutagenic inactivation of the p53 signaling pathway through the interacting protein RTN3, and proteomic analysis of HBV core protein (HBc) interactions in the nucleus of HepaRG cells revealed that the interaction of HBc with multiple RNA-binding proteins (RBPs) that regulate viral mRNA metabolism provides a new perspective to develop novel host-targeted antiviral strategies (149).