Using high-resolution mass spectrometry, 22,539 phosphorylation sites on 5431 proteins had identified in an HBx-transgenic mouse model of HCC, and these phosphoproteome data highlight potential mechanisms of kinase regulation, especially kinase activities of Src family kinases (SFKs), PKCs, MAPKs, and ROCK2 in HCC (155). Here, ROCK2 is linked to hepatocellular carcinoma.