At the transcriptome, proteome and phosphoproteome levels of liver cancer tissues, it was observed that the key enzymes of glycolysis pathway (HK2, ALDOA, PKM2) were significantly up-regulated, indicating that liver cancer has an increased demand for glucose metabolism, and phosphorylation of glycolytic enzymes including ALDOA, may drive metabolic reprogramming and proliferation in liver cancer with CTNNB1 mutation (14). The gene discussed is ALDOA; the disease is liver cancer.