In lieu of these findings, we hypothesized that NFIL3 might play a crucial role in gout progression via regulation of the REDD1/mTOR axis, and thus performed a series of experiments to investigate the association between NFIL3 and the REDD1/mTOR signaling along with their interactions in gout, aiming to uncover novel therapeutic targets against the disease. This evidence concerns the gene DDIT4 and gout.