ISG15 and Fanconi anemia: Globally, the genes in this network are involved in homologous recombination and Fanconi anemia pathways (BLM, BRCA1, BRCA2, BRCC3, BRIP1, DMC1, FANCA, RAD51, RAD51D), DNA repair and replication (PCNA, RFC5, POLD3), microtubule formation and the regulation of chromosome segregation (AURKA, TPX2, CENPE, NUF2), and immune response (EIF2AK2, IRF9, JAK2, NMI, STAT1, USP18, ISG15, CDC25C).