Globally, the genes in this network are involved in homologous recombination and Fanconi anemia pathways (BLM, BRCA1, BRCA2, BRCC3, BRIP1, DMC1, FANCA, RAD51, RAD51D), DNA repair and replication (PCNA, RFC5, POLD3), microtubule formation and the regulation of chromosome segregation (AURKA, TPX2, CENPE, NUF2), and immune response (EIF2AK2, IRF9, JAK2, NMI, STAT1, USP18, ISG15, CDC25C). The gene discussed is RFC5; the disease is Fanconi anemia.