VWA8 and familial hemiplegic migraine: VWA8 (KIAA0564) also showed putative ATPase activity expressed in the brain, as seen in patients with familial hemiplegic migraine (FHM II), where ATP1A2 is mutated, which encodes for two subunits of Na+/K+ ATPases, expressed in the adult brain (De Fusco et al., 2003).