Furthermore, a differential secretome approach of CAFs and bone marrow-derived precursors has identified in clinical CRC specimens a series of candidate biomarkers such as tenascin C, fibronectin ED-A domain and stromal-derived factor-1 (SDF1) that are associated with a CAF-specific phenotype (De Boeck et al., 2013). The gene discussed is CXCL12; the disease is colorectal carcinoma.