S100A4 and colorectal carcinoma: Furthermore, a transcriptomic analysis has also shown that CAF markers, such as α-SMA, PDGFR-β, FAP, FSP-1, are expressed in a higher level in stroma-high compared to stroma-low CRC tissues, particularly with higher FAP expression in the invasive part of tumors (Sandberg et al., 2019), together suggesting that these molecular markers, as indicative of CAFs, could play a promotive role in CRC progression.