Moreover, it has been shown that IL-6-activated STAT3 in fibroblast subpopulations regulates the transcriptional patterns associated with angiogenesis, and blockade of proangiogenic signaling impedes CRC growth in genetically modified mice with constitutive STAT3 activation in fibroblasts (Heichler et al., 2020). Here, STAT3 is linked to colorectal carcinoma.