Snail is a TGF-β target gene that mediates some pro-tumorigenic roles of TGF-β signaling (David et al., 2016; Moon et al., 2017), and is also necessary for mediating the pro-tumorigenic effects of fibroblasts on CRC cells (Herrera et al., 2014). The gene discussed is SNAI1; the disease is colorectal carcinoma.