Combining another research which shows that by secreting the LOXL2, CAFs stimulate the focal adhesion kinase (FAK) pathway and consequently induce the EMT and metastasis of CRC cells (Xuefeng et al., 2020), those research progresses characterize these signaling as vital mediators in transducing CAFs’ notorious effects on malignant behaviors of CRC. This evidence concerns the gene PTK2 and colorectal carcinoma.