ACTA1 and colorectal carcinoma: One study using a cytokine chip has found that CAFs in CRC secrete the c-type lectin domain family 3 member B (CLEC3B), and that CRC patients with combined expression of CLEC3B and α-SMA have worse survival than those with either CLEC3B or α-SMA expression alone (Zhu et al., 2019), offering CLEC3B as a potential valuable CAF-based biomarker for CRC prognosis.