NFKB1 and neoplasm: Nevertheless, using an animal model of colitis-associated cancer (CAC) and sporadic colon tumors initiated by AOM, lines of direct genetic evidence have been obtained, which uncover an unexpected tumor-suppressive role of NF-κB signaling in CAFs that confers anti-tumorigenic effects and suppresses intestinal tumorigenesis in vivo (Pallangyo et al., 2015).