CHCHD2 and amyotrophic lateral sclerosis: CHCHD2 mutations are already associated with several neurodegenerative diseases, including frontotemporal dementia (Che et al., 2018) and Parkinson’s disease (Funayama et al., 2015; Meng et al., 2017), while CHCHD10 mutations have also been found to cause ALS (Dols-Icardo et al., 2015; Zhang et al., 2015).