Secondly, in hepatocellular carcinoma, METTL3 overexpression then inhibited the expression of suppressor of cytokine signaling factor 2 (SOCS2) through an m6A-YTHDF2-dependent mechanism, which ultimately promoted tumor growth (Tuncel and Kalkan, 2019). This evidence concerns the gene METTL3 and hepatocellular carcinoma.