The mechanism is that METTL3 interacts with the microprocessor protein Dgcr8 to complete miR221/222 processing, which rescues METTL3-induced proliferation of bladder cancer cells, and its processing exerts an oncogenic effect by positively regulating the pri-miR221/222 process in an m6A-dependent manner (Gu et al., 2016). The gene discussed is METTL3; the disease is urinary bladder cancer.