AKR1C1 and neoplasm: A total of 32 ferroptosis-related genes, including 7 drivers, 11 suppressors, and 14 markers, were screened using MAD > 1 as the threshold, as described in section “Materials and methods.” Among the 32 ferroptosis-related genes, CDKN2A, GDF15, TRIB3, MYB, NOX4, PSAT1, SCD, SCL7A11, CXCL2, and NNMT were significantly upregulated in tumor samples, while AKR1C1, AKR1C2, MT1G, ATF3, SLC2A12, AKR1C3, CAV1, VLDLR, RGS4, DPP4, BNIP3, TFAP2C, CA9, PROM2, and ENPP2 were significantly upregulated in normal tissues (Supplementary Figure 1A).